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Which Means You Can Get To The Carlisle Fairgrounds Or Government Offices Within Minutes. We Are Conveniently Located Off Of Route 581 And Interstate 81. We Are Certain That You Will Relax In Our Comfortable Accommodations, And Enjoy Our Central Location Near The Area’S Many Businesses And Most Popular Attractions. We Are Located 15 Minutes From Carlisle And Harrisburg. We Are Located In The Middle Of Chain Restaurants Like Buffalo Wild Wings, Longhorn Steak House, Applebee’S And Olive Garden As Well As Wegman's And Shopping Centers. Holiday Inn Express Mechanicsburg Pa.